Abnormalities of urinary tract and skeleton associated with congenital absence of vagina.

Congenital absence of the vagina was first mentioned by Realdus Columbus in 1572 (quoted by Bryan, Nigro, and Counseller, 1949). The incidence has been variously reported as 1 in 4,000 female patients (Bryan et al., 1949), 1 in 5,000 births (Engstad, 1917), and 6 in 125,000 female hospital admissions (Owens, 1942). The largest series was reported by Phelan, Counseller, and Greene (1953), who saw 129 patients with absence of the vagina at the Mayo Clinic. Excretory urography was done on only 72, and 26 (36%) of these were found to have abnormalities of the urinary tract. A similar incidence was reported in a smaller series studied at the Johns Hopkins Hospital, where four cases out of 11 showed abnormalities of the urinary tract (Novak and Jones, 1961). Of 41 cases of this condition studied by Bryan et al. (1949) 21 showed abnormalities of the urinary